Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CCL22 MDC SCYA22 A-152E5.1

C-C motif chemokine 22

C-C motif chemokine 22 ;
CC chemokine STCP-1 ;
MDC ;
1-69 ;
Macrophage-derived chemokine ;
Small-inducible cytokine A22 ;
Stimulated T-cell chemotactic protein 1 ;
[Cleaved into: MDC ;
3-69 ;
MDC ;
5-69 ;
MDC ;
7-69 ;
]

function:May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes , dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils , eosinophils , and resting T-lymphocytes. Binds to CCR4. Processed forms MDC (3-69) , MDC (5-69) and MDC (7-69) seem not be active. ,online information:CCL22 entry ,PTM:The N-terminal processed forms MDC (3-69) , MDC (5-69) and MDC (7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes. ,similarity:Belongs to the intercrine beta (chemokine CC) family. ,tissue specificity:Highly expressed in macrophage and in monocyte-derived dendritic cells , and thymus. Also found in lymph node , appendix , activated monocytes , resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+) . Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis , allergic contact dermatitis skin , and psoriasis , in both the eptdermis and dermis. ,

cell motion , chemotaxis , defense response , inflammatory response , immune response , cell-cell signaling , behavior ,locomotory behavior , response to wounding , response to virus , cell migration , taxis , cell motility , localization of cell ,

Secreted.