Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

BMP7

Bone morphogenetic protein 7

BMP7 ;
OP1 ;
Bone morphogenetic protein 7 ;
BMP-7 ;
Osteogenic protein 1 ;
OP-1 ;
Eptotermin alfa

function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. ,online information:Bone morphogenetic protein 7 entry ,pharmaceutical:Available under the names Osigraft (Stryker) . Its use is indicated in the treatment of tibial non-union of at least 9 month duration , secondary to trauma , in skeletally mature patients , in cases where autograft has failed or is unfeasible. ,PTM:Several N-termini starting at positions 293 , 300 , 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014) . ,similarity:Belongs to the TGF-beta family. ,subunit:Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. ,tissue specificity:Expressed in the kidneys and bladder. Lower levels seen in the brain. ,

cell morphogenesis , cell morphogenesis involved in differentiation , skeletal system development , ossification , eye development , urogenital system development , formation of primary germ layer , mesoderm formation , morphogenesis of a branching structure , kidney development , epithelial to mesenchymal transition , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , protein amino acid phosphorylation ,phosphorus metabolic process , phosphate metabolic process , cell motion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , gastrulation , pattern specification process , axonogenesis , axon guidance , sensory organ development , salivary gland development , salivary gland morphogenesis , mesoderm development , response to nutrient , negative regulation of cell proliferation , response to endogenous stimulus , response to hormone stimulus ,embryonic pattern specification , positive regulation of biosynthetic process , positive regulation of signal transduction ,response to extracellular stimulus , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process ,positive regulation of gene expression , positive regulation of cell communication , negative regulation of cell development , positive regulation of pathway-restricted SMAD protein phosphorylation , regulation of cell death ,positive regulation of cell death , mesenchymal cell development , phosphorylation , regulation of phosphate metabolic process , gland morphogenesis , cell projection organization , neuron differentiation , regulation of ossification ,regulation of bone mineralization , positive regulation of bone mineralization , BMP signaling pathway , epithelial cell differentiation , embryonic camera-type eye development , neuron projection development , positive regulation of cellular biosynthetic process , regulation of protein modification process , positive regulation of protein modification process , response to nutrient levels , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , response to estradiol stimulus , cellular component morphogenesis , cell part morphogenesis , response to vitamin , response to vitamin D , tube morphogenesis , exocrine system development , tube development , growth , regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , odontogenesis of dentine-containing tooth , odontogenesis , regulation of apoptosis , camera-type eye development , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , response to peptide hormone stimulus , response to estrogen stimulus , regulation of transcription , negative regulation of cell differentiation , positive regulation of cell differentiation , regulation of osteoblast differentiation , positive regulation of osteoblast differentiation , positive regulation of ossification , negative regulation of cell cycle , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of phosphate metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , embryonic eye morphogenesis , mesoderm morphogenesis , response to steroid hormone stimulus , embryonic organ morphogenesis ,embryonic organ development , eye morphogenesis , camera-type eye morphogenesis , embryonic camera-type eye morphogenesis , embryonic morphogenesis , neuron development , cell morphogenesis involved in neuron differentiation , tissue morphogenesis , gland development , branching morphogenesis of a tube , mesenchymal cell differentiation , neuron projection morphogenesis , cell projection morphogenesis , regulation of neurogenesis , negative regulation of neurogenesis , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , cartilage development , positive regulation of multicellular organismal process , positive regulation of protein metabolic process , regulation of RNA metabolic process ,positive regulation of RNA metabolic process , regulation of cell cycle , regulation of nervous system development ,regulation of cell development , bone development , pathway-restricted SMAD protein phosphorylation , regulation of pathway-restricted SMAD protein phosphorylation , epithelium development , mesenchyme development , regulation of biomineral formation , positive regulation of biomineral formation ,

Secreted.