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Total BRSK1 Cell-Based Colorimetric ELISA Kit

-KA3827C

Catalog: KA3827C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
BRSK1
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Other Name:
Serine/threonine-protein kinase BRSK1 ;
Brain-selective kinase 1 ;
Brain-specific serine/threonine-protein kinase 1 ;
BR serine/threonine-protein kinase 1 ;
Serine/threonine-protein kinase SAD-B ;
Synapses of Amphids Defective homolog 1 ;
SAD1 homolog ;
hSAD1 ;
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Database Link:
Organism Gene ID SwissProt
Human 84446; Q8TDC3;
Mouse Q5RJI5;
Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-205 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.,tissue specificity:Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.,
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Function:
cell cycle checkpoint, DNA damage checkpoint, cell morphogenesis, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to DNA damage stimulus, establishment or maintenance of cell polarity, intracellular signaling cascade, response to radiation, response to UV, response to light stimulus,response to abiotic stimulus, response to ionizing radiation, phosphorylation, establishment of cell polarity, neuron differentiation, DNA integrity checkpoint, G2/M transition DNA damage checkpoint, G2/M transition checkpoint, cellular component morphogenesis, cellular response to stress, DNA damage response, signal transduction, regulation of cell cycle,
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Cellular Localization:
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell junction, synapse . Cell junction, synapse, presynaptic active zone . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). .
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Tissue Expression:
Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
show all
Catalog: KA3827C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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