Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FLT1

Vascular endothelial growth factor receptor 1

FLT1 ;
FLT ;
FRT ;
VEGFR1 ;
Vascular endothelial growth factor receptor 1 ;
VEGFR-1 ;
Fms-like tyrosine kinase 1 ;
FLT-1 ;
Tyrosine-protein kinase FRT ;
Tyrosine-protein kinase receptor FLT ;
FLT ;
Vascular permeability factor receptor

alternative products:Additional isoforms seem to exist ,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,function:Receptor for VEGF , VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Interacts in vitro with various phosphotyrosine-binding proteins , including PLC-gammas , PTPN11 , GRB2 , CRK and NCK1. ,tissue specificity:Mostly in normal lung , but also in placenta , liver , kidney , heart and brain tissues. Specifically expressed in most of the vascular endothelial cells , and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta. ,

MAPKKK cascade , activation of MAPKK activity , angiogenesis , blood vessel development , patterning of blood vessels ,response to hypoxia , morphogenesis of a branching structure , vasculature development , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell motion , regulation of muscle contraction , regulation of smooth muscle contraction , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , pattern specification process , female pregnancy , positive regulation of cell proliferation , positive regulation of signal transduction , positive regulation of cell communication , phosphorylation , cell migration , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , regulation of phosphate metabolic process , regulation of cell migration , positive regulation of cell migration , intracellular receptor-mediated signaling pathway , regulation of vascular endothelial growth factor receptor signaling pathway , positive regulation of vascular endothelial growth factor receptor signaling pathway , activation of protein kinase activity , positive regulation of kinase activity , tube morphogenesis , tube development , regulation of locomotion , positive regulation of locomotion ,regulation of cell proliferation , regulation of phosphorylation , positive regulation of catalytic activity , regulation of kinase activity , regulation of system process , positive regulation of molecular function , regulation of protein kinase activity , positive regulation of protein kinase activity , blood vessel morphogenesis , regulation of smooth muscle cell proliferation , positive regulation of smooth muscle cell proliferation , branching morphogenesis of a tube , cell motility ,regulation of phosphorus metabolic process , regulation of cell motion , positive regulation of cell motion , regulation of transferase activity , positive regulation of transferase activity , localization of cell , response to oxygen levels ,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 7]: Cytoplasm .