disease:May be involved in forms of prostate cancers.,function:Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.,tissue specificity:Expressed in pancreas, thymus and testis.,
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Function:
regulation of Rab GTPase activity, regulation of Ras GTPase activity, regulation of Rab protein signal transduction,regulation of GTPase activity, regulation of Ras protein signal transduction, regulation of small GTPase mediated signal transduction, regulation of hydrolase activity,
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Cellular Localization:
Cell membrane ; Lipid-anchor . Associated with lipid rafts.
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Tissue Expression:
Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.