Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

ENG

Endoglin

ENG ;
END ;
Endoglin ;
CD antigen CD105

disease:Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300 , 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1) . HHT1 is an autosomal dominant multisystemic vascular dysplasia , characterized by recurrent epistaxis , muco-cutaneous telangiectases , gastro-intestinal hemorrhage , and pulmonary (PAVM) , cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed , there is an important clinical heterogeneity. ,function:Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. ,subunit:Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1 , and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. ,tissue specificity:Endoglin is restricted to endothelial cells in all tissues except bone marrow. ,

negative regulation of transcription from RNA polymerase II promoter , chronological cell aging , angiogenesis , blood vessel development , patterning of blood vessels , vasculogenesis , response to hypoxia , morphogenesis of a branching structure , endothelial cell development , regulation of protein amino acid phosphorylation , negative regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , regulation of endothelial cell proliferation , negative regulation of endothelial cell proliferation , vasculature development , heart looping , epithelial cell development , heart morphogenesis , circulatory system process , detection of oxygen , regulation of systemic arterial blood pressure , positive regulation of systemic arterial blood pressure , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , cell motion , chemotaxis , cell adhesion ,cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , pattern specification process , heart development , muscle organ development , aging , cell aging , behavior ,locomotory behavior , blood circulation , regulation of blood pressure , negative regulation of cell proliferation , detection of chemical stimulus , response to wounding , negative regulation of biosynthetic process , positive regulation of biosynthetic process , positive regulation of signal transduction , negative regulation of signal transduction , regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter , negative regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , negative regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression , positive regulation of cell communication , negative regulation of cell communication , positive regulation of pathway-restricted SMAD protein phosphorylation ,establishment of endothelial blood-brain barrier , cell migration , negative regulation of transcription , regulation of transforming growth factor beta receptor signaling pathway , regulation of phosphate metabolic process , central nervous system vasculogenesis , cellular component disassembly , biological adhesion , extracellular matrix disassembly ,regulation of cell adhesion , extracellular matrix organization , BMP signaling pathway , regulation of BMP signaling pathway , negative regulation of transforming growth factor beta receptor signaling pathway , positive regulation of BMP signaling pathway , epithelial cell differentiation , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , regulation of protein modification process , negative regulation of protein modification process , positive regulation of protein modification process , regulation of protein amino acid autophosphorylation , negative regulation of protein amino acid autophosphorylation , regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , negative regulation of gene-specific transcription , regulation of gene-specific transcription ,regulation of monooxygenase activity , negative regulation of monooxygenase activity , tube morphogenesis , tube development , wound healing , regulation of cell proliferation , regulation of phosphorylation , negative regulation of phosphorylation , positive regulation of phosphorylation , taxis , extracellular structure organization , negative regulation of catalytic activity , positive regulation of gene-specific transcription , negative regulation of molecular function ,endothelial cell differentiation , regulation of transcription , positive regulation of blood pressure , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , negative regulation of phosphate metabolic process , positive regulation of phosphate metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , blood vessel morphogenesis , smooth muscle tissue development , branching morphogenesis of a tube , artery morphogenesis , venous blood vessel morphogenesis , cell motility , regulation of nitric-oxide synthase activity , negative regulation of nitric-oxide synthase activity , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process ,positive regulation of protein metabolic process , negative regulation of protein metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process ,regulation of oxidoreductase activity , negative regulation of oxidoreductase activity , detection of stimulus , localization of cell , cell chemotaxis , regulation of pathway-restricted SMAD protein phosphorylation , negative regulation of pathway-restricted SMAD protein phosphorylation , epithelium development , muscle tissue development , response to oxygen levels , detection of hypoxia ,

Cell membrane ; Single-pass type I membrane protein .