MAEA

Macrophage erythroblast attacher ;
Cell proliferation-inducing gene 5 protein ;
Erythroblast macrophage protein ;
Human lung cancer oncogene 10 protein ;
HLC-10 ;

developmental stage:Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis.,function:Play a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.,similarity:Contains 1 CTLH domain.,similarity:Contains 1 LisH domain.,subcellular location:Localized as nuclear speckled-like pattern.,subunit:Form a complex with F-actin.,tissue specificity:Ubiquitous.,

immune system development, cytoskeleton organization, cell cycle, cell adhesion, regulation of mitotic cell cycle,regulation of cell death, developmental maturation, biological adhesion, hemopoiesis, myeloid cell differentiation,erythrocyte differentiation, regulation of myeloid cell apoptosis, negative regulation of myeloid cell apoptosis,erythrocyte homeostasis, homeostatic process, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, erythrocyte maturation, enucleate erythrocyte differentiation, cell maturation, hemopoietic or lymphoid organ development, erythrocyte development,enucleate erythrocyte development, homeostasis of number of cells, cell division, regulation of cell cycle, negative regulation of cell death,

Cytoplasm . Nucleus, nucleoplasm . Nucleus matrix . Cell membrane . Cytoplasm, cytoskeleton . Detected in a nuclear, speckled-like pattern (PubMed:16510120). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity). .

Detected at macrophage membranes (at protein level). Ubiquitous.