Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL6R

Interleukin-6 receptor subunit alpha

IL6R ;
Interleukin-6 receptor subunit alpha ;
IL-6 receptor subunit alpha ;
IL-6R subunit alpha ;
IL-6R-alpha ;
IL-6RA ;
IL-6R 1 ;
Membrane glycoprotein 80 ;
gp80 ;
CD antigen CD126

domain:The two fibronectin type-III-like domains , contained in the N-terminal part , form together a cytokine-binding domain. ,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. ,function:Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. ,function:Part of the receptor for interleukin 6. Binds to IL6 with low affinity , but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response , acute-phase reactions and hematopoiesis. ,PTM:A short soluble form may also be released from the membrane by proteolysis. ,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily. ,similarity:Contains 1 fibronectin type-III domain. ,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain. ,subunit:Hexamer of two molecules each of IL6 , IL6R and IL6ST. ,tissue specificity:Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum. ,

regulation of cytokine production , negative regulation of cytokine production , positive regulation of cytokine production , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , response to molecule of bacterial origin , organ or tissue specific immune response , immune effector process , hepatic immune response , leukocyte mediated immunity , myeloid leukocyte mediated immunity , neutrophil mediated immunity , acute inflammatory response , monocyte chemotaxis , positive regulation of immune system process , regulation of leukocyte migration , positive regulation of leukocyte migration , regulation of leukocyte chemotaxis , positive regulation of leukocyte chemotaxis , cell motion , chemotaxis , defense response , acute-phase response , inflammatory response , immune response , behavior , locomotory behavior , positive regulation of cell proliferation , response to radiation , response to wounding , response to bacterium , response to abiotic stimulus ,response to endogenous stimulus , response to hormone stimulus , negative regulation of biosynthetic process ,positive regulation of signal transduction , response to organic substance , response to ionizing radiation , response to gamma radiation , regulation of activation of Janus kinase activity , positive regulation of activation of Janus kinase activity , negative regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of cell communication , regulation of collagen metabolic process , negative regulation of collagen metabolic process , positive regulation of protein kinase cascade ,regulation of cell death , cell migration , regulation of phosphate metabolic process , cytokine-mediated signaling pathway , regulation of ossification , regulation of cell migration , positive regulation of cell migration , leukocyte chemotaxis , pancreas development , endocrine pancreas development , regulation of protein modification process ,positive regulation of protein modification process , response to corticosteroid stimulus , regulation of response to external stimulus , positive regulation of response to external stimulus , regulation of cellular protein metabolic process ,positive regulation of cellular protein metabolic process , response to lipopolysaccharide , regulation of chemokine production , regulation of interleukin-6 production , regulation of interleukin-8 production , negative regulation of interleukin-8 production , positive regulation of chemokine production , positive regulation of interleukin-6 production ,regulation of collagen biosynthetic process , negative regulation of collagen biosynthetic process , response to cytokine stimulus , endocrine system development , regulation of locomotion , positive regulation of locomotion , regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , taxis , regulation of tyrosine phosphorylation of STAT protein , regulation of tyrosine phosphorylation of Stat3 protein , positive regulation of tyrosine phosphorylation of Stat3 protein , positive regulation of tyrosine phosphorylation of STAT protein , defense response to bacterium , regulation of apoptosis , regulation of programmed cell death , regulation of MAPKKK cascade ,positive regulation of MAPKKK cascade , response to peptide hormone stimulus , regulation of multicellular organismal metabolic process , negative regulation of multicellular organismal metabolic process , response to ethanol , positive regulation of cell differentiation , regulation of osteoblast differentiation , positive regulation of osteoblast differentiation , regulation of anti-apoptosis , positive regulation of anti-apoptosis , positive regulation of phosphate metabolic process , regulation of JAK-STAT cascade , positive regulation of JAK-STAT cascade , positive regulation of behavior , response to steroid hormone stimulus , positive regulation of response to stimulus , regulation of smooth muscle cell proliferation , positive regulation of smooth muscle cell proliferation , cell motility , regulation of peptidyl-tyrosine phosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , regulation of behavior , defense response to Gram-negative bacterium , defense response to Gram-positive bacterium , leukocyte migration , regulation of chemotaxis , positive regulation of chemotaxis , positive regulation of developmental process , regulation of phosphorus metabolic process , positive regulation of multicellular organismal process , negative regulation of multicellular organismal process , positive regulation of protein metabolic process , regulation of cell motion , positive regulation of cell motion , response to glucocorticoid stimulus , response to cAMP , localization of cell , cell chemotaxis ,interleukin-6-mediated signaling pathway , ciliary neurotrophic factor-mediated signaling pathway ,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .; [Soluble interleukin-6 receptor subunit alpha]: Secreted .