cofactor:FAD.,function:Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.,induction:Up-regulated by androgens, including testosterone and dihydrotestosterone.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,tissue specificity:Ubiquitous. Highly expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine.,
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Function:
transition metal ion transport, ion transport, cation transport, iron ion transport, di-, tri-valent inorganic cation transport, metal ion transport, fat cell differentiation, oxidation reduction,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .