Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL27/EBI3

Interleukin-27 subunit alpha/Interleukin-27 subunit beta

IL27 ;
IL27A ;
Interleukin-27 subunit alpha ;
IL-27 subunit alpha ;
IL-27-A ;
IL27-A ;
p28 ;
EBI3 ;
IL27B ;
Interleukin-27 subunit beta ;
IL-27 subunit beta ;
IL-27B ;
Epstein-Barr virus-induced gene 3 protein ;
EBV-induced gene 3 protein

function:Cytokine with pro- and anti-inflammatory properties , that can regulate T helper cell development , suppress T-cell proliferation , stimulate cytotoxic T cell activity , induce isotype switching in B-cells , and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1) , type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17) . It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells , binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways , p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1 , STAT3 , STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation , an event crucial to TH1 cell commitment. It suppresses the expression of GATA3 , the inhibitor TH1 cells development. In CD8 T-cells , it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1 , it inhibits the development of anti-inflammatory inducible regulatory T-cells , iTreg , independently of STAT1. IL-27 has also an effect on cytokine production , it suppresses proinflammatory cytokine production such as IL2 , IL4 , IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production , IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells , it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replivation. ,induction:Transiently induced by LPS stimulation in monocytes. ,online information:Interleukin-27 entry ,PTM:O-glycosylated. ,similarity:Belongs to the IL-6 superfamily. ,subcellular location:Does not seem to be secreted without coexpression of EBI3. ,subunit:Heterodimer with IL27B/EBI3. IL-27 is an heterodimer composed IL27 and EBI3. EBI3 is also a component of the IL-12 heterodimer. ,tissue specificity:Expressed in monocytes and in placenta. ,

regulation of cytokine production , regulation of leukocyte activation , regulation of immune effector process , regulation of adaptive immune response , regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , regulation of T-helper 1 type immune response , regulation of response to biotic stimulus , defense response , inflammatory response , immune response , response to wounding ,positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of cellular biosynthetic process , regulation of interferon-gamma production , regulation of mononuclear cell proliferation , regulation of cytokine biosynthetic process ,positive regulation of cytokine biosynthetic process , regulation of cell proliferation , regulation of T cell proliferation ,regulation of CD4-positive , alpha beta T cell differentiation , regulation of multi-organism process , regulation of interferon-gamma biosynthetic process , positive regulation of interferon-gamma biosynthetic process , innate immune response , regulation of T cell differentiation , regulation of lymphocyte differentiation , regulation of T-helper cell differentiation , regulation of T-helper 1 cell differentiation , regulation of alpha-beta T cell activation , regulation of alpha-beta T cell differentiation , regulation of lymphocyte proliferation , regulation of defense response to virus ,regulation of T cell activation , regulation of cell activation , regulation of lymphocyte activation , regulation of leukocyte proliferation ,

Secreted . Does not seem to be secreted without coexpression of EBI3.