Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL15

Interleukin-15

IL15 ;
Interleukin-15 ;
IL-15

function:Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R , including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. ,online information:Interleukin-15 entry ,sequence caution:Man-made cDNA construct with a sequence coding for signal peptide increasing the secretion of the protein (substitution with a signal peptide derived from the mouse IgV kappa chain) . ,similarity:Belongs to the IL-15/IL-21 family. ,subcellular location:IL15-S21AA is not secreted , but rather is stored intracellularly , appearing in the nucleus and cytoplasmic components. ,tissue specificity:Most abundant in placenta and skeletal muscle. It is also detected in the heart , lung , liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus. ,

cell activation , NK T cell proliferation , immune system development , leukocyte differentiation , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of immune effector process , regulation of response to biotic stimulus , defense response , inflammatory response , immune response , cell-cell signaling , aging , cell proliferation , positive regulation of cell proliferation , negative regulation of cell proliferation , response to wounding , hemopoiesis , lymphocyte differentiation , T cell differentiation , mononuclear cell proliferation , regulation of mononuclear cell proliferation , positive regulation of mononuclear cell proliferation ,extrathymic T cell differentiation , T cell proliferation , positive regulation of T cell proliferation , T cell activation ,regulation of cell proliferation , regulation of T cell proliferation , regulation of multi-organism process , T cell selection ,extrathymic T cell selection , leukocyte activation , regulation of T cell differentiation , regulation of lymphocyte differentiation , alpha-beta T cell activation , alpha-beta T cell proliferation , lymphocyte activation , lymphocyte proliferation , hemopoietic or lymphoid organ development , lymph node development , positive regulation of response to stimulus , regulation of smooth muscle cell proliferation , negative regulation of smooth muscle cell proliferation ,regulation of lymphocyte proliferation , positive regulation of lymphocyte proliferation , regulation of defense response to virus , regulation of defense response to virus by host , positive regulation of immune response , regulation of T cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of T cell activation ,regulation of lymphocyte activation , positive regulation of lymphocyte activation , leukocyte proliferation , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation ,

[Isoform IL15-S48AA]: Secreted.; [Isoform IL15-S21AA]: Cytoplasm. Nucleus. IL15-S21AA is not secreted , but rather is stored intracellularly , appearing in the nucleus and cytoplasmic components.