MAPKAPK3

MAP kinase-activated protein kinase 3 ;
MAPK-activated protein kinase 3 ;
MAPKAP kinase 3 ;
MAPKAP-K3 ;
MAPKAPK-3 ;
MK-3 ;
Chromosome 3p kinase ;
3pK ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly located in the nucleus, when activated it translocates to the cytoplasm.,subunit:Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.,tissue specificity:Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction, phosphorylation,

Nucleus . Cytoplasm . Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Expressed in the retinal pigment epithelium (PubMed:26744326).