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Total B-ATF Cell-Based Colorimetric ELISA Kit

-KA3766C

Catalog: KA3766C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
BATF
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Other Name:
Basic leucine zipper transcriptional factor ATF-like ;
B-cell-activating transcription factor ;
B-ATF ;
SF-HT-activated gene 2 protein ;
SFA-2 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 10538; Q16520;
Mouse O35284;
Background:
function:Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) (consensus: 5'-TGA[CG]TCA-3') and weaker at the cAMP-responsive region (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), but are transcriptionally inert.,PTM:Phosphorylated.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Forms heterodimers with JUN, JUNB and JUND. Also interacts with IFI35.,tissue specificity:Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. According to PubMed:10777209 also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow.,
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Function:
transcription, regulation of transcription, DNA-dependent, regulation of transcription, regulation of RNA metabolic process,
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Cellular Localization:
Nucleus . Cytoplasm . Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. .
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Tissue Expression:
Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).
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Catalog: KA3766C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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