NAB2

NGFI-A-binding protein 2 ;
EGR-1-binding protein 2 ;
Melanoma-associated delayed early response protein ;
Protein MADER ;

domain:The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.,domain:The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.,function:Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.,induction:By serum and PMA stimulation.,similarity:Belongs to the NAB family.,subcellular location:Isoform 2 is not localized to the nucleus.,subunit:Homomultimers may associate with EGR1 bound to DNA.,tissue specificity:Widely expressed at low levels. Highly expressed in melanoma cell lines.,

skeletal system development, ossification, regulation of action potential, endochondral ossification, transcription,cellular ion homeostasis, ensheathment of neurons, peripheral nervous system development, cell proliferation, axon ensheathment, negative regulation of biosynthetic process, glial cell differentiation, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, Schwann cell differentiation, negative regulation of transcription, transmission of nerve impulse,regulation of action potential in neuron, cellular homeostasis, negative regulation of cellular biosynthetic process,gliogenesis, regulation of membrane potential, myelination, homeostatic process, regulation of transcription,regulation of epidermis development, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, skeletal system morphogenesis, chemical homeostasis, ion homeostasis, neurological system process, negative regulation of nitrogen compound metabolic process, cellular chemical homeostasis, bone development, bone morphogenesis, endochondral bone morphogenesis,

Nucleus . Isoform 2 is not localized to the nucleus. .

Widely expressed at low levels. Highly expressed in melanoma cell lines.