MED1

Mediator of RNA polymerase II transcription subunit 1 ;
Activator-recruited cofactor 205 kDa component ;
ARC205 ;
Mediator complex subunit 1 ;
Peroxisome proliferator-activated receptor-binding protein ;
PBP ;
PPAR-binding protein ;
Thyroid hormone receptor-associated protein complex 220 kDa component ;
Trap220 ;
Thyroid receptor-interacting protein 2 ;
TR-interacting protein 2 ;
TRIP-2 ;
Vitamin D receptor-interacting protein complex component DRIP205 ;
p53 regulatory protein RB18A ;

function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.,PTM:Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus. Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the Mediator complex subunit 1 family.,subcellular location:A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.,subunit:Interacts with GATA1 and YWHAH (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Binds DNA.,tissue specificity:Ubiquitously expressed.,

eye development, in utero embryonic development, liver development, placenta development, embryonic placenta development, immune system development, DNA metabolic process, DNA replication, transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, protein complex assembly, thyroid hormone generation, intracellular signaling cascade, sensory organ development, heart development, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of hormone levels, hemopoiesis, embryonic limb morphogenesis, steroid hormone receptor signaling pathway, androgen receptor signaling pathway, intracellular receptor-mediated signaling pathway, positive regulation of cellular biosynthetic process, RNA biosynthetic process,embryonic heart tube development, appendage morphogenesis, limb morphogenesis, embryonic appendage morphogenesis, embryonic hindlimb morphogenesis, hindlimb morphogenesis, embryonic hemopoiesis, tube development, thyroid hormone metabolic process, hormone metabolic process, chordate embryonic development,camera-type eye development, macromolecular complex subunit organization, fat cell differentiation, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, hemopoietic or lymphoid organ development, embryonic organ development,embryonic morphogenesis, appendage development, positive regulation of nitrogen compound metabolic process,regulation of RNA metabolic process, positive regulation of RNA metabolic process, limb development, macromolecular complex assembly, protein complex biogenesis,

Nucleus . A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.

Ubiquitously expressed.