Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TNFSF12

Tumor necrosis factor ligand superfamily member 12

TNFSF12 ;
APO3L ;
DR3LG ;
Tumor necrosis factor ligand superfamily member 12 ;
APO3 ligand ;
TNF-related weak inducer of apoptosis ;
TWEAK

function:Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. ,function:Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. ,induction:Down-regulated by phorbol myristate acetate/ionomycin treatment. ,PTM:The precursor is cleaved by furin. ,PTM:The soluble form derives from the membrane form by proteolytic processing. ,similarity:Belongs to the tumor necrosis factor family. ,subunit:Homotrimer (Potential) . Interacts with the angiogenic factor AGGF1/VG5Q. ,subunit:Homotrimer . ,tissue specificity:Expressed at high levels in transformed cell lines , cancers of colon , thyroid , lymphoid tissues and specifically expressed in monocytes and macrophages. ,tissue specificity:Highly expressed in adult heart , pancreas , skeletal muscle , brain , colon , small intestine , lung , ovary , prostate , spleen , lymph node , appendix and peripheral blood lymphocytes. Low expression in kidney , testis , liver , placenta , thymus and bone marrow. Also detected in fetal kidney , liver , lung and brain. ,

Cell membrane ; Single-pass type II membrane protein .; [Tumor necrosis factor ligand superfamily member 12 , secreted form]: Secreted.; [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein.