Catalog: KE1068
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Specificity
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Storage
2-8°C/6 months,Ship by ice bag
Modification
Unmodified
Sample Type
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Detection Method
Colorimetric
Sensitivity
32-2000 pg/ml
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Antigen&Target Information
Specificity:
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
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Gene Name:
TNFSF10
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Protein Name:
Tumor necrosis factor ligand superfamily member 10
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Other Name:
TNFSF10 ;
APO2L ;
TRAIL ;
Tumor necrosis factor ligand superfamily member 10 ;
Apo-2 ligand ;
Apo-2L ;
TNF-related apoptosis-inducing ligand ;
Protein TRAIL ;
CD antigen CD253
APO2L ;
TRAIL ;
Tumor necrosis factor ligand superfamily member 10 ;
Apo-2 ligand ;
Apo-2L ;
TNF-related apoptosis-inducing ligand ;
Protein TRAIL ;
CD antigen CD253
show all
Background:
cofactor:Binds 1 zinc ion per trimer. ,function:Cytokine that binds to TNFRSF10A/TRAILR1 , TNFRSF10B/TRAILR2 , TNFRSF10C/TRAILR3 , TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3 , TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. ,similarity:Belongs to the tumor necrosis factor family. ,subunit:Homotrimer. ,tissue specificity:Widespread; most predominant in spleen , lung and prostate. ,
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Function:
apoptosis , induction of apoptosis , immune response , cell-cell signaling , cell death , activation of pro-apoptotic gene products , positive regulation of signal transduction , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death , positive regulation of cell death ,programmed cell death , induction of programmed cell death , death , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade ,
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Cellular Localization:
Cell membrane ; Single-pass type II membrane protein . Secreted . Exists both as membrane-bound and soluble form. .
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Tissue Expression:
Signaling Pathway
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
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Catalog: KE1068
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
Add to cart
Collected
Collect
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