Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

KITLG

Kit ligand

KITLG ;
MGF ;
SCF ;
Kit ligand ;
Mast cell growth factor ;
MGF ;
Stem cell factor ;
SCF ;
c-Kit ligand

developmental stage:Acts in the early stages of hematopoiesis. ,function:Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines , probably interleukins. ,polymorphism:Genetic variations in KITLG are associated with variation in skin/hair/eye pigmentation type 7 (SHEP7) [MIM:611664]. Hair , eye and skin pigmentation are among the most visible examples of human phenotypic variation , with a broad normal range that is subject to substantial geographic stratification. In the case of skin , individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast , the majority of variation in human eye and hair color is found among individuals of European ancestry , with most other human populations fixed for brown eyes and black hair. ,PTM:A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain. ,PTM:Found in two differentially glycosylated forms , LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145 , partially N-glycosylated at Asn-90 , O-glycosylated at Ser-167 , Thr-168 and Thr-180 , and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118 , Asn-90 and Asn-145 , O-glycosylated at Ser-167 , Thr-168 and Thr-180 , and not glycosylated at Asn-97. ,similarity:Belongs to the SCF family. ,subcellular location:Also exists as a secreted soluble form (isoform 1 only) . ,subunit:Homodimer , non-covalently linked. ,

ameboidal cell migration , neural crest cell migration , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , immune system development , regulation of myeloid leukocyte differentiation , positive regulation of myeloid leukocyte differentiation , regulation of DNA replication , cell motion , cell adhesion , cell proliferation , positive regulation of cell proliferation , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , mesenchymal cell development , neural crest cell development , neural crest cell differentiation , cell migration , regulation of phosphate metabolic process , biological adhesion , hemopoiesis ,positive regulation of cellular biosynthetic process , regulation of protein modification process , positive regulation of protein modification process , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , positive regulation of kinase activity , regulation of cell proliferation , regulation of phosphorylation ,positive regulation of phosphorylation , positive regulation of catalytic activity , regulation of MAP kinase activity ,positive regulation of MAP kinase activity , regulation of kinase activity , positive regulation of molecular function ,positive regulation of cell differentiation , regulation of melanocyte differentiation , positive regulation of melanocyte differentiation , regulation of myeloid cell differentiation , positive regulation of myeloid cell differentiation , positive regulation of DNA replication , regulation of protein kinase activity , positive regulation of protein kinase activity ,positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of phosphate metabolic process , regulation of pigmentation during development , positive regulation of pigmentation during development , hemopoietic or lymphoid organ development , mesenchymal cell differentiation , cell motility ,regulation of peptidyl-tyrosine phosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , regulation of pigment cell differentiation , positive regulation of pigment cell differentiation , regulation of DNA metabolic process ,positive regulation of DNA metabolic process , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , positive regulation of protein metabolic process , regulation of transferase activity , positive regulation of transferase activity , localization of cell ,mesenchyme development ,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm . Cytoplasm , cytoskeleton . Cell membrane ; Single-pass type I membrane protein . Cell projection , lamellipodium . Cell projection , filopodium .; [Soluble KIT ligand]: Secreted.