Catalog: KE1057
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Specificity
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Storage
2-8°C/6 months,Ship by ice bag
Modification
Unmodified
Sample Type
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Detection Method
Colorimetric
Sensitivity
16-2000 pg/ml
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RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
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Antigen&Target Information
Specificity:
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
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Gene Name:
PGF
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Protein Name:
Placenta growth factor
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Other Name:
PGF ;
PGFL ;
PLGF ;
Placenta growth factor ;
PlGF
PGFL ;
PLGF ;
Placenta growth factor ;
PlGF
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Background:
domain:PLGF-2 contains a basic insert which acts as a cell retention signal. ,function:Growth factor active in angiogenesis , and endothelial cell growth , stimulating their proliferation and migration. It binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner. ,PTM:N-glycosylated. ,similarity:Belongs to the PDGF/VEGF growth factor family. ,subcellular location:The three forms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. ,subunit:Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGF/VEGF-A. PlGF-3 is found both as homodimer and as monomer. ,tissue specificity:While the three forms are present in most placental tissues , the PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. ,
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Function:
angiogenesis , blood vessel development , urogenital system development , metanephros development , ureteric bud development , branching involved in ureteric bud morphogenesis , response to hypoxia , morphogenesis of a branching structure , kidney development , regulation of endothelial cell proliferation , positive regulation of endothelial cell proliferation , vasculature development , morphogenesis of an epithelium , cell-cell signaling , female pregnancy , cell proliferation , positive regulation of cell proliferation , response to endogenous stimulus , response to hormone stimulus ,response to organic substance , cellular response to hormone stimulus , tube morphogenesis , tube development ,regulation of cell proliferation , response to drug , blood vessel morphogenesis , tissue morphogenesis , branching morphogenesis of a tube , regulation of cell division , positive regulation of cell division , epithelium development ,epithelial tube morphogenesis , ureteric bud morphogenesis , response to oxygen levels ,
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Cellular Localization:
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
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Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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Catalog: KE1057
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
Add to cart
Collected
Collect
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