Catalog: KE1055
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Specificity
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Storage
2-8°C/6 months,Ship by ice bag
Modification
Unmodified
Sample Type
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
Detection Method
Colorimetric
Sensitivity
23-3000 pg/ml
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Antigen&Target Information
Specificity:
Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
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Gene Name:
SERPINE1
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Protein Name:
Plasminogen activator inhibitor 1
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Other Name:
SERPINE1 ;
PAI1 ;
PLANH1 ;
Plasminogen activator inhibitor 1 ;
PAI ;
PAI-1 ;
Endothelial plasminogen activator inhibitor ;
Serpin E1
PAI1 ;
PLANH1 ;
Plasminogen activator inhibitor 1 ;
PAI ;
PAI-1 ;
Endothelial plasminogen activator inhibitor ;
Serpin E1
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Background:
disease:Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) [MIM:173360]. This deficiency is characterized by abnormal bleeding due to SERPINE1 defect in the plasma. ,disease:High concentrations of SERPINE1 have been associated with thrombophilia [MIM:188050]; an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis. ,function:This inhibitor acts as 'bait' for tissue plasminogen activator , urokinase , and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. ,online information:Plasminogen activator inhibitor-1 entry ,PTM:Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA) , cleaving the 369-Arg-|-Met-370 bond. ,similarity:Belongs to the serpin family. ,subunit:Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. ,tissue specificity:Found in plasma and platelets and in endothelial , hepatoma and fibrosarcoma cells. ,
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Function:
response to reactive oxygen species , chronological cell aging , response to oxidative stress , aging , cell aging , blood coagulation , hemostasis , response to wounding , response to inorganic substance , regulation of blood coagulation ,negative regulation of blood coagulation , regeneration , regulation of response to external stimulus , carbohydrate homeostasis , growth , wound healing , regulation of cell proliferation , tissue regeneration , homeostatic process ,glucose homeostasis , fibrinolysis , regulation of angiogenesis , developmental growth , chemical homeostasis ,coagulation , regulation of coagulation , negative regulation of coagulation , regulation of body fluid levels , negative regulation of multicellular organismal process ,
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Cellular Localization:
Secreted .
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Signaling Pathway
Cellular Processes >> Cell growth and death >> p53 signaling pathway
Cellular Processes >> Cell growth and death >> Cellular senescence
Organismal Systems >> Immune system >> Complement and coagulation cascades
Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
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Catalog: KE1055
Size
Price
Status
Qty.
5*96well
$1,850.00
2 weeks
0
2*96well
$740.00
2 weeks
0
96well
$370.00
2 weeks
0
Add to cart
Collected
Collect
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