GTF2H2

General transcription factor IIH subunit 2 ;
Basic transcription factor 2 44 kDa subunit ;
BTF2 p44 ;
General transcription factor IIH polypeptide 2 ;
TFIIH basal transcription factor complex p44 subunit ;

alternative products:A number of isoforms may be produced. The isoforms may be also produced by incomplete gene duplication,function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.,function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.,similarity:Belongs to the GTF2H2 family.,similarity:Contains 1 VWFA domain.,subunit:One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3.,tissue specificity:Widely expressed, with higher expression in skeletal muscle.,

nucleotide-excision repair, DNA damage removal, desensitization of G-protein coupled receptor protein signaling pathway, G-protein coupled receptor internalization, DNA metabolic process, DNA repair, nucleotide-excision repair,DNA catabolic process, transcription, transcription, DNA-dependent, transcription initiation, RNA elongation,transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, protein complex assembly, endocytosis, receptor-mediated endocytosis,response to DNA damage stimulus, regulation of G-protein coupled receptor protein signaling pathway, macromolecule catabolic process, response to radiation, response to UV, response to light stimulus, response to abiotic stimulus,negative regulation of signal transduction, membrane invagination, negative regulation of cell communication,membrane organization, vesicle-mediated transport, adaptation of signaling pathway, receptor internalization, RNA biosynthetic process, cellular response to stress, receptor metabolic process, macromolecular complex subunit organization, cellular macromolecule catabolic process, regulation of transcription, negative regulation of G-protein coupled receptor protein signaling pathway, macromolecular complex assembly, protein complex biogenesis,

Nucleus .

Widely expressed, with higher expression in skeletal muscle.