DYRK1A

Dual specificity tyrosine-phosphorylation-regulated kinase 1A ;
Dual specificity YAK1-related kinase ;
HP86 ;
Protein kinase minibrain homolog ;
MNBH ;
hMNB ;

alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,developmental stage:Expressed in the developing central nervous system.,disease:Overexpressed 1.5-fold in fetal Down syndrome brain.,enzyme regulation:Inhibited by RANBP9.,function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.,PTM:Autophosphorylated on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9.,tissue specificity:Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, protein amino acid autophosphorylation,

Nucleus . Nucleus speckle .

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.