Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FGF2

Fibroblast growth factor 2

FGF2 ;
FGFB ;
Fibroblast growth factor 2 ;
FGF-2 ;
Basic fibroblast growth factor ;
bFGF ;
Heparin-binding growth factor 2 ;
HBGF-2

function:The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. ,miscellaneous:This protein binds heparin more strongly than does aFGF. ,PTM:Several N-termini starting at positions 48 , 54 , 47 and 65 have been identified by direct sequencing. ,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon. ,similarity:Belongs to the heparin-binding growth factors family. ,subunit:Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1 , FGF1 and FGF2. ,tissue specificity:Expressed in granulosa and cumulus cells. ,

protein import into nucleus , translocation , MAPKKK cascade , activation of MAPKK activity , activation of MAPK activity ,nuclear translocation of MAPK , angiogenesis , regulation of cell growth , blood vessel development , cell fate specification , induction of an organ , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , vasculature development , sprouting angiogenesis , cell migration during sprouting angiogenesis , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , protein amino acid phosphorylation , protein targeting , protein import into nucleus , steroid biosynthetic process , C21-steroid hormone biosynthetic process , phosphorus metabolic process , phosphate metabolic process ,intracellular protein transport , nucleocytoplasmic transport , apoptosis , cell motion , chemotaxis , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , small GTPase mediated signal transduction , Ras protein signal transduction , cell-cell signaling , synaptic transmission , behavior , locomotory behavior , protein localization , steroid metabolic process , C21-steroid hormone metabolic process , cell death , positive regulation of cell proliferation , negative regulation of cell proliferation , regulation of cell size , fibroblast growth factor receptor signaling pathway , lipid biosynthetic process , response to wounding , negative regulation of biosynthetic process , positive regulation of biosynthetic process , glial cell differentiation , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , regulation of endothelial cell migration , positive regulation of endothelial cell migration , negative regulation of endothelial cell migration , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression ,regulation of hormone levels , regulation of cell death , programmed cell death , protein transport , regulation of striated muscle tissue development , death , phosphorylation , cell migration , negative regulation of transcription , protein import ,regulation of exocytosis , regulation of calcium ion-dependent exocytosis , regulation of phosphate metabolic process ,transmission of nerve impulse , regulation of granule cell precursor proliferation , positive regulation of granule cell precursor proliferation , negative regulation of cell growth , respiratory tube development , lung development ,regulation of cell migration , positive regulation of cell migration , negative regulation of cell migration , developmental induction , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process ,regulation of protein modification process , positive regulation of protein modification process , activation of protein kinase activity , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , regulation of cellular component size , protein localization in organelle , positive regulation of kinase activity ,protein localization in nucleus , cellular protein localization , cellular hormone metabolic process , tube development ,regulation of growth , regulation of locomotion , negative regulation of locomotion , positive regulation of locomotion ,wound healing , gliogenesis , regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , taxis , hormone metabolic process , hormone biosynthetic process , regulation of programmed cell death , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , blood vessel endothelial cell migration , regulation of blood vessel endothelial cell migration , positive regulation of blood vessel endothelial cell migration , negative regulation of blood vessel endothelial cell migration ,endothelial cell migration , regulation of kinase activity , positive regulation of molecular function , cell fate commitment ,cell-cell signaling involved in cell fate specification , establishment of protein localization , regulation of transcription ,positive regulation of cell differentiation , regulation of angiogenesis , positive regulation of angiogenesis , negative regulation of cell size , regulation of protein kinase activity , positive regulation of protein kinase activity , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of growth , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of phosphate metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , regulation of organ growth , regulation of retinal cell programmed cell death , intracellular transport , blood vessel morphogenesis , regulation of muscle development , regulation of developmental growth , cell motility , regulation of epithelial cell proliferation , positive regulation of epithelial cell proliferation , neurological system process , regulation of secretion , positive regulation of developmental process , nuclear transport , nuclear import , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , positive regulation of multicellular organismal process , positive regulation of protein metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of cell motion , negative regulation of cell motion , positive regulation of cell motion , regulation of cell division , regulation of transferase activity , positive regulation of transferase activity ,localization of cell , positive regulation of cell division , regulation of nervous system development , regulation of cardiac muscle growth , regulation of cardiac muscle tissue development , regulation of cardiac muscle cell proliferation , positive regulation of cardiac muscle cell proliferation , regulation of cell development , regulation of cellular localization ,regulation of heart growth , respiratory system development , regulation of vesicle-mediated transport , cellular macromolecule localization ,

Secreted . Nucleus . Exported from cells by an endoplasmic reticulum (ER) /Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531) . Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063) . Nuclear import from the cytosol requires the classical nuclear import machinery , involving proteins KPNA1 and KPNB1 , as well as CEP57 (PubMed:22321063) . .