Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

PROK1 UNQ600/PRO1186

Prokineticin-1

PROK1 ;
Prokineticin-1 ;
Endocrine-gland-derived vascular endothelial growth factor ;
EG-VEGF ;
Mambakine

developmental stage:In adult testis , is strongly expressed only in Leydig cells. In testicular tumors , expressed specifically in Leydig cell tumors (at protein level) . Expressed from 14 weeks until birth in fetal testis. ,function:Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation , migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation , but not migration , of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. ,similarity:Belongs to the AVIT (prokineticin) family. ,tissue specificity:Localizes to glandular epithelium , stroma and vascular epithelial cells of first trimester decidua (at protein level) . Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands , ovary , testis , adrenal and placenta. ,

MAPKKK cascade , activation of MAPK activity , angiogenesis , blood vessel development , vasculature development ,protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , protein kinase cascade , positive regulation of cell proliferation , phosphorylation , regulation of phosphate metabolic process , positive regulation of kinase activity , regulation of cell proliferation , regulation of phosphorylation , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of kinase activity , positive regulation of molecular function , regulation of angiogenesis ,regulation of protein kinase activity , positive regulation of protein kinase activity , blood vessel morphogenesis ,regulation of phosphorus metabolic process , regulation of cell division , regulation of transferase activity , positive regulation of transferase activity , positive regulation of cell division ,

Secreted.