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Total ETO-2 Cell-Based Colorimetric ELISA Kit

-KA3691C

Catalog: KA3691C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CBFA2T3
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Other Name:
Protein CBFA2T3 ;
MTG8-related protein 2 ;
Myeloid translocation gene on chromosome 16 protein ;
hMTG16 ;
Zinc finger MYND domain-containing protein 4 ;
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Database Link:
Organism Gene ID SwissProt
Human 863; O75081;
Mouse O54972;
Background:
disease:A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.,function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).,induction:Down-regulated by all-trans retinoic acid.,similarity:Belongs to the CBFA2T family.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 1 TAFH (NHR1) domain.,subcellular location:The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.,subunit:Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity). Heterodimer with RUNX1T1 and CBFA2T2. Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According to Hoogeveen et al (PubMed:12242670) may not interact with HDAC6. Isoform 2 interacts with PRKAR2A, PDE7A and probably PDE4A.,tissue specificity:Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).,
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Function:
transcription, regulation of transcription, DNA-dependent, cell proliferation, regulation of transcription, regulation of RNA metabolic process,
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Cellular Localization:
[Isoform 1]: Nucleus, nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm . Golgi apparatus membrane .
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Tissue Expression:
Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
show all
Catalog: KA3691C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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