Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

DEFB103A/DEFB103B

Beta-defensin 103

DEFB103A ;
BD3 ;
DEFB103 ;
DEFB3 ;
DEFB103B ;
Beta-defensin 103 ;
Beta-defensin 3 ;
BD-3 ;
DEFB-3 ;
HBD3 ;
hBD-3 ;
Defensin ;
beta 103 ;
Defensin-like protein

function:Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes , Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistent E.faecium. No significant hemolytic activity was observed. ,induction:By infection of bacteria and by interferon gamma. ,mass spectrometry: PubMed:11085990 ,similarity:Belongs to the beta-defensin family. ,tissue specificity:Highly expressed in skin and tonsils , and to a lesser extent in trachea , uterus , kidney , thymus , adenoid , pharynx and tongue. Low expression in salivary gland , bone marrow , colon , stomach , polyp and larynx. No expression in small intestine. ,

regulation of immune effector process , regulation of production of molecular mediator of immune response , regulation of antimicrobial humoral response , regulation of antimicrobial peptide production , regulation of antibacterial peptide production , regulation of antimicrobial peptide biosynthetic process , positive regulation of antimicrobial peptide biosynthetic process , regulation of antibacterial peptide biosynthetic process , regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria , regulation of response to biotic stimulus , regulation of humoral immune response , defense response , positive regulation of antibacterial peptide biosynthetic process ,positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria , response to bacterium , positive regulation of biosynthetic process , positive regulation of cellular biosynthetic process , defense response to bacterium , regulation of multi-organism process ,

Secreted.