domain:N-terminus mediates homodimerization.,domain:The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3.,function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.,PTM:The N-terminus is blocked.,similarity:Contains 6 WD repeats.,subunit:Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.,
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Function:
RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, nuclear mRNA splicing, via spliceosome, mRNA polyadenylation, mRNA cleavage, RNA processing, mRNA processing, RNA splicing, mRNA metabolic process, RNA 3'-end processing, mRNA 3'-end processing, RNA polyadenylation,