CREM

cAMP-responsive element modulator ;
Inducible cAMP early repressor ;
ICER ;

caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.,PTM:Stimulated by phosphorylation.,sequence caution:Translated as Tyr.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Binds DNA as a dimer. Interacts with FHL5.,tissue specificity:Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.,

monosaccharide metabolic process, glucose metabolic process, transcription, regulation of transcription, DNA-dependent, fatty acid metabolic process, membrane lipid metabolic process, glycolipid metabolic process, sphingolipid metabolic process, glycosphingolipid metabolic process, intracellular signaling cascade, gamete generation,spermatogenesis, hexose metabolic process, sexual reproduction, intracellular receptor-mediated signaling pathway,multicellular organism reproduction, regulation of circadian rhythm, regulation of transcription, male gamete generation, retinoic acid receptor signaling pathway, reproductive process in a multicellular organism, regulation of RNA metabolic process,

Nucleus.; [Isoform 6]: Cytoplasm . Nucleus .

Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.