Catalog: KA3663C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
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Collected
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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KE1372
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Antigen&Target Information
Gene Name:
ADARB1
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Other Name:
Double-stranded RNA-specific editase 1 ;
RNA-editing deaminase 1 ;
RNA-editing enzyme 1 ;
dsRNA adenosine deaminase ;
RNA-editing deaminase 1 ;
RNA-editing enzyme 1 ;
dsRNA adenosine deaminase ;
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Background:
alternative products:Additional isoforms seem to exist,cofactor:Binds 1 inositol hexakisphosphate (IP6) per subunit.,function:Editing of the messenger RNAs for glutamate receptor (GluR) subunits by site-selective adenosine deamination. Edits both the GluR-B Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently.,similarity:Contains 1 A to I editase domain.,similarity:Contains 2 DRBM (double-stranded RNA-binding) domains.,
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Function:
RNA processing, mRNA processing, RNA modification, mRNA metabolic process, base conversion or substitution editing,
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Cellular Localization:
Nucleus . Nucleus, nucleolus . Shuttles between nucleoli and the nucleoplasm. .; [Isoform 1]: Nucleus . Nucleus, nucleolus .; [Isoform 2]: Nucleus . Nucleus, nucleolus .
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Tissue Expression:
Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). ; [Isoform 5]: Highly expressed in hippocampus and colon. Expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.
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Reference Citation({{totalcount}})
Catalog: KA3663C
Size
Price
Status
Qty.
96well
$330.00
In stock
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Add to cart
Collected
Collect
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