PKIA

cAMP-dependent protein kinase inhibitor alpha ;
PKI-alpha ;
cAMP-dependent protein kinase inhibitor, muscle/brain isoform ;

function:Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.,miscellaneous:The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.,similarity:Belongs to the PKI family.,

negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, negative regulation of protein kinase activity, regulation of mitotic cell cycle, negative regulation of biosynthetic process, regulation of G2/M transition of mitotic cell cycle,negative regulation of macromolecule biosynthetic process, regulation of cell cycle process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription,regulation of phosphate metabolic process, negative regulation of cellular biosynthetic process, regulation of intracellular transport, negative regulation of intracellular transport, regulation of protein localization, regulation of intracellular protein transport, negative regulation of kinase activity, regulation of protein import into nucleus,negative regulation of protein import into nucleus, regulation of phosphorylation, negative regulation of catalytic activity, regulation of kinase activity, negative regulation of molecular function, regulation of transcription, regulation of protein kinase activity, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of nucleocytoplasmic transport, negative regulation of nucleocytoplasmic transport, negative regulation of transport, negative regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, regulation of protein transport, negative regulation of protein transport, regulation of RNA metabolic process, negative regulation of RNA metabolic process, regulation of transferase activity, negative regulation of transferase activity, regulation of cell cycle, regulation of cellular localization, regulation of establishment of protein localization,