Catalog: KA3646C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
Related Products
ELISA Kits
Total ELL Cell-Based Colorimetric ELISA Kit
KA3646C
More→
ELISA Kits
Human TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit
KE1372
More→
ELISA Kits
Human RNASE3/ECP(Ribonuclease A3/Eosinophil Cationic Protein) ELISA Kit
KE1709
More→
Antigen&Target Information
Gene Name:
ELL
show all
Other Name:
RNA polymerase II elongation factor ELL ;
Eleven-nineteen lysine-rich leukemia protein ;
Eleven-nineteen lysine-rich leukemia protein ;
show all
Background:
disease:A chromosomal translocation involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.,function:Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ELL/occludin family.,subcellular location:Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies.,subunit:Interacts with EAF1 and EAF2.,tissue specificity:Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.,
show all
Function:
in utero embryonic development, transcription, transcription, DNA-dependent, RNA elongation, transcription from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, embryonic development ending in birth or egg hatching, RNA biosynthetic process, chordate embryonic development, regulation of transcription,
show all
Cellular Localization:
Nucleus . Nucleus speckle . Nucleus, Cajal body . Colocalizes with EAF2 to nuclear speckles (PubMed:12446457). Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606). Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes(PubMed:23932780). .
show all
Tissue Expression:
Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
show all
Reference Citation({{totalcount}})
Catalog: KA3646C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}