BMX

Cytoplasmic tyrosine-protein kinase BMX ;
Bone marrow tyrosine kinase gene in chromosome X protein ;
Epithelial and endothelial tyrosine kinase ;
ETK ;
NTK38 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Binds 1 zinc ion per subunit.,domain:SH2 domain mediates interaction with RUFY1.,function:Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.,induction:Activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RUFY1 and RUFY2.,tissue specificity:Preferentially expressed in epithelial and endothelial cells.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, mesoderm development, phosphorylation,

Cytoplasm . Localizes to the edges of spreading cells when complexed with BCAR1.

Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.