Catalog: KA3624C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
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Main Information
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
TNFSF10
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Other Name:
Tumor necrosis factor ligand superfamily member 10 ;
Apo-2 ligand ;
Apo-2L ;
TNF-related apoptosis-inducing ligand ;
Protein TRAIL ;
CD antigen CD253 ;
Apo-2 ligand ;
Apo-2L ;
TNF-related apoptosis-inducing ligand ;
Protein TRAIL ;
CD antigen CD253 ;
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Background:
cofactor:Binds 1 zinc ion per trimer.,function:Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Widespread; most predominant in spleen, lung and prostate.,
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Function:
apoptosis, induction of apoptosis, immune response, cell-cell signaling, cell death, activation of pro-apoptotic gene products, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, positive regulation of cell death,programmed cell death, induction of programmed cell death, death, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade,
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Cellular Localization:
Cell membrane ; Single-pass type II membrane protein . Secreted . Exists both as membrane-bound and soluble form. .
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Tissue Expression:
Widespread; most predominant in spleen, lung and prostate.
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
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Catalog: KA3624C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
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