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Total Casein Kinase Iε Cell-Based Colorimetric ELISA Kit

-KA3617C

Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CSNK1E
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Other Name:
Casein kinase I isoform epsilon ;
CKI-epsilon ;
CKIe ;
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Database Link:
Organism Gene ID SwissProt
Human 102800317; P49674;
Mouse Q9JMK2;
Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.,induction:Down-regulated during granulocytic differentiation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with ANKRD6 and SOCS3.,tissue specificity:Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.,
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Function:
DNA metabolic process, DNA repair, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to DNA damage stimulus, phosphorylation, cellular response to stress,
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Cellular Localization:
Cytoplasm . Nucleus .
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Tissue Expression:
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
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Catalog: KA3617C
Size
Price
Status
Qty.
96well
$330.00
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