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Total ALK-1 Cell-Based Colorimetric ELISA Kit

-KA3599C

Catalog: KA3599C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
ACVRL1
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Other Name:
Serine/threonine-protein kinase receptor R3 ;
SKR3 ;
Activin receptor-like kinase 1 ;
ALK-1 ;
TGF-B superfamily receptor type I ;
TSR-I ;
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Database Link:
Organism Gene ID SwissProt
Human 94; P37023;
Mouse Q61288;
Rat P80203;
Background:
catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,
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Function:
angiogenesis, regulation of cell growth, blood vessel development, in utero embryonic development, vasculature development, regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, circulatory system process, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell motion, negative regulation of cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, blood circulation, regulation of blood pressure, negative regulation of cell proliferation, regulation of cell size, response to wounding, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, positive regulation of signal transduction, positive regulation of macromolecule biosynthetic process, regulation of endothelial cell migration, negative regulation of endothelial cell migration, positive regulation of macromolecule metabolic process, positive regulation of gene expression, positive regulation of cell communication, regulation of cell-substrate adhesion, negative regulation of cell-substrate adhesion,phosphorylation, cell migration, regulation of cell adhesion, negative regulation of cell growth, regulation of cell migration, negative regulation of cell migration, regulation of BMP signaling pathway, positive regulation of BMP signaling pathway, positive regulation of cellular biosynthetic process, regulation of cellular component size, wound healing, spreading of epidermal cells, regulation of growth, regulation of locomotion, negative regulation of locomotion, wound healing, regulation of cell proliferation, chordate embryonic development, regulation of cellular component biogenesis, regulation of transcription, negative regulation of cell size, negative regulation of growth,positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, blood vessel morphogenesis, cell motility, negative regulation of cellular component organization,positive regulation of nitrogen compound metabolic process, regulation of cell motion, negative regulation of cell motion, localization of cell, regulation of focal adhesion formation, negative regulation of focal adhesion formation,
show all
Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
show all
Catalog: KA3599C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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