SOX6

Transcription factor SOX-6

function:Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.,PTM:Sumoylation inhibits the transcriptional activity.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Interacts with DAZAP2.,tissue specificity:Expressed in a wide variety of tissues, most abundantly in skeletal muscle.,

negative regulation of transcription from RNA polymerase II promoter, cell morphogenesis, skeletal system development, immune system development, chromatin organization, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, heart development, muscle organ development, post-embryonic development, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, gene silencing,negative regulation of transcription, hemopoiesis, myeloid cell differentiation, erythrocyte differentiation, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, cellular component morphogenesis, erythrocyte homeostasis, cardiac cell differentiation, homeostatic process, muscle cell differentiation,cell fate commitment, regulation of transcription, negative regulation of transcription, DNA-dependent, positive regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, hemopoietic or lymphoid organ development, erythrocyte development, homeostasis of number of cells, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, cartilage development, regulation of RNA metabolic process, negative regulation of RNA metabolic process, positive regulation of RNA metabolic process, chromosome organization,

Nucleus . Cytoplasm .

Expressed in a wide variety of tissues, most abundantly in skeletal musclen.