CALR

Calreticulin ;
CRP55 ;
Calregulin ;
Endoplasmic reticulum resident protein 60 ;
ERp60 ;
HACBP ;
grp60 ;

caution:Was originally (PubMed:2332496) thought to be the 52 kDa Ro autoantigen.,domain:Associates with PDIA3 through the tip of the extended arm formed by the P-domain.,domain:Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.,domain:The interaction with glycans occurs through a binding site in the globular lectin domain.,domain:The zinc binding sites are localized to the N-domain.,function:Molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.,mass spectrometry: PubMed:11149926,online information:Calreticulin,online information:Calreticulin entry,similarity:Belongs to the calreticulin family.,subcellular location:Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.,subunit:Monomer. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and with NR3C1.,

negative regulation of transcription from RNA polymerase II promoter, MHC protein complex assembly, MHC class I protein complex assembly, antigen processing and presentation of peptide antigen via MHC class I, peptide antigen assembly with MHC protein complex, peptide antigen assembly with MHC class I protein complex, regulation of DNA replication, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,regulation of translation, protein folding, protein complex assembly, protein targeting, protein export from nucleus,cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, intracellular protein transport, nucleocytoplasmic transport, cytoskeleton organization, cell cycle, cell cycle arrest, intracellular signaling cascade, aging, protein localization, positive regulation of cell proliferation, negative regulation of biosynthetic process, positive regulation of biosynthetic process, negative regulation of signal transduction, senescence, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process,regulation of cell cycle process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, negative regulation of gene expression, negative regulation of cell communication, regulation of cell death, protein transport, negative regulation of transcription, negative regulation of translation, cellular homeostasis, antigen processing and presentation, cell cycle process, protein maturation by protein folding, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, actin filament-based process, actin cytoskeleton organization, regulation of endocytosis, steroid hormone receptor signaling pathway, intracellular receptor-mediated signaling pathway, cortical cytoskeleton organization, cortical actin cytoskeleton organization, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of protein stability, corticosteroid receptor signaling pathway,regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of steroid hormone receptor signaling pathway, negative regulation of steroid hormone receptor signaling pathway,cellular protein localization, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, regulation of meiosis, regulation of cell proliferation, homeostatic process, glucocorticoid receptor signaling pathway, regulation of apoptosis, regulation of programmed cell death, cellular protein complex assembly,macromolecular complex subunit organization, establishment of protein localization, regulation of transcription,negative regulation of cell differentiation, regulation of neuron differentiation, negative regulation of neuron differentiation, positive regulation of DNA replication, positive regulation of cell cycle, positive regulation of endocytosis, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, intracellular transport, antigen processing and presentation of peptide antigen, regulation of retinoic acid receptor signaling pathway, negative regulation of retinoic acid receptor signaling pathway, chemical homeostasis, regulation of phagocytosis, positive regulation of phagocytosis, regulation of neurogenesis, ion homeostasis, protein stabilization, positive regulation of transport, regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of cellular component organization, nuclear export, nuclear transport, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, sequestering of calcium ion, maintenance of location, sequestering of metal ion, negative regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, regulation of meiotic cell cycle, protein maturation, regulation of cell cycle, regulation of nervous system development, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, regulation of cell development, regulation of vesicle-mediated transport,macromolecular complex assembly, protein complex biogenesis, cellular macromolecule localization,

Endoplasmic reticulum lumen . Cytoplasm, cytosol . Secreted, extracellular space, extracellular matrix . Cell surface . Sarcoplasmic reticulum lumen . Cytoplasmic vesicle, secretory vesicle, Cortical granule . Cytolytic granule . Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity). .