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Total Myf-6 Cell-Based Colorimetric ELISA Kit

-KA3566C

Catalog: KA3566C
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Price
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96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
MYF6
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Other Name:
Myogenic factor 6 ;
Myf-6 ;
Class C basic helix-loop-helix protein 4 ;
bHLHc4 ;
Muscle-specific regulatory factor 4 ;
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Database Link:
Organism Gene ID SwissProt
Human 4618; P23409;
Mouse P15375;
Rat P19335;
Background:
disease:Defects in MYF6 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.,function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein.,tissue specificity:Skeletal muscle.,
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Function:
somitogenesis, regionalization, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, pattern specification process, muscle organ development, skeletal muscle tissue development, response to wounding, embryonic development ending in birth or egg hatching, negative regulation of biosynthetic process, positive regulation of biosynthetic process, anterior/posterior pattern formation, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, striated muscle tissue development, negative regulation of transcription, regeneration, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, segmentation, growth, wound healing, tissue regeneration, chordate embryonic development, skeletal muscle regeneration, regulation of transcription, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, developmental growth, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, muscle tissue development, skeletal muscle organ development,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Skeletal muscle.
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Catalog: KA3566C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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