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Total PKA IIα reg Cell-Based Colorimetric ELISA Kit

-KA3541C

Catalog: KA3541C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
PRKAR2A
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Other Name:
cAMP-dependent protein kinase type II-alpha regulatory subunit
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Database Link:
Organism Gene ID SwissProt
Human 5576; P13861;
Mouse P12367;
Background:
function:Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.,PTM:Phosphorylated by the activated catalytic chain.,similarity:Belongs to the cAMP-dependent kinase regulatory chain family.,similarity:Contains 2 cyclic nucleotide-binding domains.,subunit:The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3.,tissue specificity:Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.,
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Function:
regulation of protein amino acid phosphorylation, intracellular signaling cascade, response to endogenous stimulus,response to hormone stimulus, hormone-mediated signaling, response to organic substance, regulation of phosphate metabolic process, regulation of protein modification process, activation of protein kinase activity, regulation of cellular protein metabolic process, cellular response to hormone stimulus, positive regulation of kinase activity, activation of protein kinase A activity, regulation of phosphorylation, positive regulation of catalytic activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity,
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Cellular Localization:
Cytoplasm . Cell membrane . Colocalizes with PJA2 in the cytoplasm and the cell membrane.
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Tissue Expression:
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
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Catalog: KA3541C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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