NGFR

Tumor necrosis factor receptor superfamily member 16 ;
Gp80-LNGFR ;
Low affinity neurotrophin receptor p75NTR ;
Low-affinity nerve growth factor receptor ;
NGF receptor ;
p75 ICD ;
CD antigen CD271 ;

domain:Death domain is responsible for interaction with RANBP9.,domain:The extracellular domain is responsible for interaction with NTRK1.,function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1.,

cell morphogenesis, cell morphogenesis involved in differentiation, hair follicle development, proteolysis, apoptosis,anti-apoptosis, induction of apoptosis, cell motion, ectoderm development, axonogenesis, axon guidance, cell death,positive regulation of cell proliferation, epidermis development, induction of apoptosis by extracellular signals,macromolecule catabolic process, response to temperature stimulus, detection of external stimulus, detection of abiotic stimulus, response to wounding, response to abiotic stimulus, negative regulation of signal transduction,negative regulation of cell communication, positive regulation of cell development, negative regulation of cell development, regulation of cell morphogenesis involved in differentiation, regulation of cell death, positive regulation of cell death, regulation of neuron projection development, programmed cell death, induction of programmed cell death, detection of temperature stimulus, death, nerve development, molting cycle process, hair cycle process,regulation of cell morphogenesis, cell projection organization, protein catabolic process, neuron differentiation, hair follicle morphogenesis, neuron projection development, membrane protein intracellular domain proteolysis, regulation of cell projection organization, negative regulation of cell projection organization, positive regulation of cell projection organization, cellular component morphogenesis, cell part morphogenesis, membrane protein proteolysis, regulation of fibroblast growth factor receptor signaling pathway, negative regulation of fibroblast growth factor receptor signaling pathway, regulation of cell proliferation, molting cycle, regulation of odontogenesis, positive regulation of odontogenesis, regulation of odontogenesis of dentine-containing tooth, positive regulation of odontogenesis of dentine-containing tooth, hair cycle, regulation of hair cycle, regulation of apoptosis, positive regulation of apoptosis,negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death,negative regulation of programmed cell death, skin development, cellular protein catabolic process, cellular macromolecule catabolic process, negative regulation of cell differentiation, positive regulation of cell differentiation,regulation of neuron differentiation, regulation of epidermis development, negative regulation of epidermis development, negative regulation of cell cycle, regulation of fibroblast proliferation, positive regulation of fibroblast proliferation, regulation of muscle development, negative regulation of muscle development, neuron development, cell morphogenesis involved in neuron differentiation, tissue morphogenesis, epidermis morphogenesis, neuron projection morphogenesis, cell projection morphogenesis, regulation of neurogenesis, negative regulation of neurogenesis,positive regulation of neurogenesis, regulation of axonogenesis, negative regulation of axonogenesis, positive regulation of axonogenesis, positive regulation of developmental process, negative regulation of cellular component organization, positive regulation of cellular component organization, negative regulation of multicellular organismal process, proteolysis involved in cellular protein catabolic process, detection of stimulus, regulation of cell cycle,regulation of hair follicle development, negative regulation of hair follicle development, regulation of nervous system development, regulation of cell development, negative regulation of cell death,

Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine .