ALDOA

Fructose-bisphosphate aldolase A ;
Lung cancer antigen NY-LU-1 ;
Muscle-type aldolase ;

catalytic activity:D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.,disease:Defects in ALDOA are the cause of aldolase A deficiency [MIM:611881]; also known as aldoA deficiency or red cell aldolase deficiency. Aldolase A deficiency is an autosomal recessive disorder associated with hereditary hemolytic anemia.,miscellaneous:In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.,similarity:Belongs to the class I fructose-bisphosphate aldolase family.,subunit:Homotetramer.,

muscle system process, monosaccharide metabolic process, fructose metabolic process, glucose metabolic process,glucose catabolic process, generation of precursor metabolites and energy, glycolysis, purine nucleotide metabolic process, purine nucleotide biosynthetic process, ATP biosynthetic process, muscle contraction, striated muscle contraction, cytoskeleton organization, actin filament organization, regulation of cell shape, nucleoside triphosphate metabolic process, nucleoside triphosphate biosynthetic process, purine nucleoside triphosphate metabolic process,purine nucleoside triphosphate biosynthetic process, purine ribonucleotide metabolic process, purine ribonucleotide biosynthetic process, nucleotide biosynthetic process, ribonucleoside triphosphate metabolic process, ribonucleoside triphosphate biosynthetic process, purine ribonucleoside triphosphate metabolic process, purine ribonucleoside triphosphate biosynthetic process, ribonucleotide metabolic process, ribonucleotide biosynthetic process,carbohydrate catabolic process, hexose metabolic process, hexose catabolic process, cellular homeostasis, regulation of cell morphogenesis, actin filament-based process, actin cytoskeleton organization, fructose 1,6-bisphosphate metabolic process, nucleobase, nucleoside and nucleotide biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process, homeostatic process, nitrogen compound biosynthetic process, cellular carbohydrate catabolic process, ATP metabolic process, alcohol catabolic process, monosaccharide catabolic process,muscle maintenance, anatomical structure homeostasis,

Cytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, M line . In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). .