HEXIM1

Protein HEXIM1 ;
Cardiac lineage protein 1 ;
Estrogen down-regulated gene 1 protein ;
Hexamethylene bis-acetamide-inducible protein 1 ;
Menage a quatre protein 1 ;

domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.,miscellaneous:Inhibits Tat activity which is required for HIV-1 transcription.,similarity:Belongs to the HEXIM family.,subcellular location:Binds alpha-importin and is mostly nuclear.,subunit:Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA.,tissue specificity:Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.,

regulation of cyclin-dependent protein kinase activity, negative regulation of transcription from RNA polymerase II promoter, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, negative regulation of protein kinase activity, heart development, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription, regulation of phosphate metabolic process, negative regulation of cellular biosynthetic process, negative regulation of kinase activity,regulation of phosphorylation, negative regulation of catalytic activity, regulation of kinase activity, negative regulation of molecular function, regulation of transcription, negative regulation of cyclin-dependent protein kinase activity,negative regulation of cell cycle, regulation of protein kinase activity, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, regulation of transferase activity, negative regulation of transferase activity, regulation of cell cycle,

Nucleus . Cytoplasm . Binds alpha-importin and is mostly nuclear (PubMed:16362050).

Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.