function:Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.,tissue specificity:Expressed in lymphoid tissues, B-cell lines and activated B-cells.,
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Function:
transcription, transcription, DNA-dependent, transcription from RNA polymerase II promoter, RNA biosynthetic process,regulation of transcription,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Expressed in lymphoid tissues, B-cell lines and activated B-cells.