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Total hnRNP Q Cell-Based Colorimetric ELISA Kit

-KA3475C

Catalog: KA3475C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
SYNCRIP
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Other Name:
Heterogeneous nuclear ribonucleoprotein Q ;
hnRNP Q ;
Glycine- and tyrosine-rich RNA-binding protein ;
GRY-RBP ;
NS1-associated protein 1 ;
Synaptotagmin-binding, cytoplasmic RNA-interacting protein ;
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Database Link:
Organism Gene ID SwissProt
Human 10492; O60506;
Mouse Q7TMK9;
Rat Q7TP47;
Background:
domain:The domain containing eight Arg-Gly-Gly repeats may be involved in RNA-binding and protein-protein interactions.,function:Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.,PTM:Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 413.,similarity:Contains 3 RRM (RNA recognition motif) domains.,subcellular location:Expressed predominantly in the nucleoplasm.,subcellular location:The tyrosine phosphorylated form bound to RNA is found in microsomes.,subunit:Isoform 1 is a component of the APOB mRNA editosome complex and interacts with APOBEC1 and A1CF (APOBEC1 complementation factor). Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP. Isoform 3 interacts with HNRPR. Interacts with POLR2A hyperphosphorylated C-terminal domain. Interacts with minute virus of mice (MVM) NS1 protein. Isoform 1, isoform 2 and isoform 3 interact with SMN. Isoform 3 interacts through its C-terminal domain with SYT7, SYT8 and SYT9 (By similarity). The non-phosphorylated and phosphorylated forms are colocalized with PAIP1 in polysomes (By similarity). Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.,tissue specificity:Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.,
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Function:
RNA processing, mRNA processing, RNA splicing, posttranscriptional regulation of gene expression, mRNA metabolic process, regulation of RNA stability, regulation of mRNA stability, RNA stabilization, mRNA stabilization, regulation of RNA metabolic process,
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Cellular Localization:
Cytoplasm . Microsome . Endoplasmic reticulum . Nucleus . The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). .; [Isoform 1]: Nucleus, nucleoplasm . Expressed predominantly in the nucleoplasm. .; [Isoform 2]: Nucleus, nucleoplasm . Expressed predominantly in the nucleoplasm. .; [Isoform 3]: Nucleus, nucleoplasm . Expressed predominantly in the nucleoplasm. .
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Tissue Expression:
Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.
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Catalog: KA3475C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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