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Total Hairless Cell-Based Colorimetric ELISA Kit

-KA3466C

Catalog: KA3466C
Size
Price
Status
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96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
HR
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Other Name:
Protein hairless
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Database Link:
Organism Gene ID SwissProt
Human 55806; O43593;
Mouse Q61645;
Background:
alternative products:Additional isoforms seem to exist,disease:Defects in HR are the cause of alopecia universalis congenita (ALUNC) [MIM:203655]. ALUNC is a rare autosomal recessive form of hair loss characterized by hair follicles without hair.,disease:Defects in HR are the cause of atrichia with papular lesions (APL) [MIM:209500]; also known as congenital atrichia. APL is an autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair.,function:May act as a transcription factor that could act on to regulate one of the phases of hair growth.,similarity:Contains 1 JmjC domain.,tissue specificity:Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis and isoform 2 exclusively at high levels in the skin.,
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Function:
transcription, regulation of transcription, DNA-dependent, protein complex assembly, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription,negative regulation of cellular biosynthetic process, negative regulation of DNA binding, negative regulation of transcription factor activity, macromolecular complex subunit organization, negative regulation of molecular function,regulation of transcription, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of transcription factor activity, regulation of binding, negative regulation of binding, regulation of DNA binding, negative regulation of nitrogen compound metabolic process, regulation of RNA metabolic process,protein oligomerization, protein heterooligomerization, macromolecular complex assembly, protein complex biogenesis,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin.
show all
Catalog: KA3466C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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