function:Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Associates with the actin stress fibers.,subunit:Interacts with alpha-actinins 1, 2 and 4.,tissue specificity:Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.,
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Function:
response to hypoxia, response to oxidative stress, regulation of transcription, response to oxygen levels,
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Cellular Localization:
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Associates with actin stress fibers. .
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Tissue Expression:
Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.