XRCC2

DNA repair protein XRCC2 ;
X-ray repair cross-complementing protein 2 ;

function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure.,

M phase, double-strand break repair via homologous recombination, recombinational repair, in utero embryonic development, DNA metabolic process, DNA repair, double-strand break repair, DNA recombination, response to DNA damage stimulus, cell cycle, meiosis, response to radiation, response to abiotic stimulus, embryonic development ending in birth or egg hatching, response to X-ray, response to ionizing radiation, response to gamma radiation,positive regulation of cell development, regulation of cell death, cell cycle process, cell cycle phase, cellular response to stress, regulation of apoptosis, chordate embryonic development, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, regulation of neuron apoptosis, negative regulation of neuron apoptosis, positive regulation of cell differentiation, regulation of neurogenesis, positive regulation of neurogenesis, positive regulation of developmental process, meiotic cell cycle, M phase of meiotic cell cycle, regulation of nervous system development, regulation of cell development, negative regulation of cell death,

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .