Catalog: KA3401C
Size
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96well
$330.00
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0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
SAE1
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Other Name:
SUMO-activating enzyme subunit 1 ;
Ubiquitin-like 1-activating enzyme E1A ;
Ubiquitin-like 1-activating enzyme E1A ;
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Background:
function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,tissue specificity:Expression level increases during S phase and drops in G2 phase (at protein level).,
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Function:
proteolysis, macromolecule catabolic process, protein ubiquitination, modification-dependent protein catabolic process,protein catabolic process, protein modification by small protein conjugation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Expression level increases during S phase and drops in G2 phase (at protein level).
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Signaling Pathway
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Catalog: KA3401C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
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