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Total TIMP-3 Cell-Based Colorimetric ELISA Kit

-KA3399C

Catalog: KA3399C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
TIMP3
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Other Name:
Metalloproteinase inhibitor 3 ;
Protein MIG-5 ;
Tissue inhibitor of metalloproteinases 3 ;
TIMP-3 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 7078; P35625;
Mouse P39876;
Rat P48032;
Background:
disease:Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.,function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,
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Function:
response to acid, induction of apoptosis, aging, response to nutrient, sensory perception, visual perception, induction of apoptosis by extracellular signals, response to wounding, response to mechanical stimulus, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, regulation of catabolic process, negative regulation of catabolic process, response to extracellular stimulus, response to organic substance, response to organic nitrogen, negative regulation of macromolecule metabolic process, regulation of cell death, positive regulation of cell death, induction of programmed cell death, response to organic cyclic substance, response to amine stimulus,regulation of proteolysis, regeneration, regulation of cellular catabolic process, negative regulation of cellular catabolic process, response to nutrient levels, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, response to vitamin, growth, wound healing, regulation of protein catabolic process,negative regulation of protein catabolic process, tissue regeneration, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, response to amino acid stimulus, response to estrogen stimulus, negative regulation of proteolysis, response to steroid hormone stimulus,developmental growth, neurological system process, cognition, sensory perception of light stimulus, regulation of membrane protein ectodomain proteolysis, negative regulation of membrane protein ectodomain proteolysis, negative regulation of protein metabolic process, response to folic acid,
show all
Cellular Localization:
Secreted, extracellular space, extracellular matrix.
show all
Catalog: KA3399C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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