THRA

Thyroid hormone receptor alpha ;
Nuclear receptor subfamily 1 group A member 1 ;
V-erbA-related protein 7 ;
EAR-7 ;
c-erbA-1 ;
c-erbA-alpha ;

domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. High affinity receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13.,

skeletal system development, cartilage condensation, ossification, transcription, transcription, DNA-dependent,regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, cell adhesion, intracellular signaling cascade, regulation of heart contraction,response to endogenous stimulus, response to hormone stimulus, hormone-mediated signaling, negative regulation of biosynthetic process, positive regulation of biosynthetic process, response to organic substance, regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process,negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process,negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, cell-cell adhesion, negative regulation of transcription, biological adhesion, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of gene-specific transcription, RNA biosynthetic process, cellular response to hormone stimulus, negative regulation of DNA binding,negative regulation of transcription factor activity, regulation of system process, negative regulation of molecular function, regulation of transcription, positive regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, skeletal system morphogenesis, regulation of transcription factor activity, regulation of binding, negative regulation of binding, regulation of DNA binding, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, cartilage development, regulation of RNA metabolic process, positive regulation of RNA metabolic process, bone development,

Nucleus.; [Isoform Alpha-2]: Cytoplasm . Nucleus . When overexpressed found in the cytoplasm where it colocalizes with TACC1. .